Long‐term adrenalectomy decreases NMDA receptors in rat hippocampus
作者:
H. Mangat,
A. Islam,
C. Heigensköld,
A. Mustafa,
B. Winblad,
A. Adem,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 9
页码: 2011-2014
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Adrenalectomy;Glucocorticoids;Hippo-campus;Neurodegeneration;NMDA receptors
数据来源: OVID
摘要:
THE effect of long-term adrenalectomy on NMDA receptors in the rat hippocampus was studied. Hippocampal sections of control and adrenalectomized rats were incubated with [3H]MK-801, a radiolabeled non-competitive inhibitor of the NMDA receptor. Analysis byin vitroautoradiography showed a significant decrease in [3H]MK-801 binding in the dentate gyrus, CA1 and CA4 areas, as well as the temporal cortex. Results of this study suggest that glucocorticoids are vital for the regulation of the NMDA receptors.
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