The dependence of the rate of BP metabolism in the rat small intestinal mucosa on the composition of the dietary fat
作者:
GowerJonD.,
WillsEricD.,
期刊:
Nutrition and Cancer
(Taylor Available online 1986)
卷期:
Volume 8,
issue 3
页码: 151-161
ISSN:0163-5581
年代: 1986
DOI:10.1080/01635588609513889
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractWe studied the effects that dietary fat has on the capacity of preparations of rat small intestinal mucosal cells to metabolize benzo[a]pyrene (BP) in vitro and on the composition of fatty acids in the endoplasmic reticulum of the intestinal mucosa. When rats were fed diets containing different types of fat, there were significant changes in the incorporation of fatty acids into the endoplasmic reticulum of the mucosal cells of the small intestine: the proportions of polyunsaturated fatty acids in the endoplasmic reticulum reflected the amounts of these fatty acids in the dietary fat. The rate of BP oxidation in the intestinal mucosa was dependent on the amount and composition of the dietary fat, but the range and proportions of the metabolites produced were not affected. Dietary C18:2was particularly important in elevating the rate of BP oxidation, but dietary C20:5and C22:6also effectively increased the rate of BP oxidation. The rate of BP oxidation in the small intestine of rats fed different diets was positively correlated with the proportion of polyunsaturated fatty acids in the endoplasmic reticulum of the mucosal cells.
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