首页   按分类浏览 期刊浏览 卷期浏览 FURTHER EVIDENCE FOR THE DIENONE-IMINE INTERMEDIATE IN THE FISCHER INDOLE SYNTHESIS: AN...
FURTHER EVIDENCE FOR THE DIENONE-IMINE INTERMEDIATE IN THE FISCHER INDOLE SYNTHESIS: AN UNCATALYZED FISCHER REACTION UNDER MILD CONDITIONS

 

作者: F. P. Robinson,   R. K. Brown,  

 

期刊: Canadian Journal of Chemistry  (NRC Available online 1964)
卷期: Volume 42, issue 8  

页码: 1940-1947

 

ISSN:0008-4042

 

年代: 1964

 

DOI:10.1139/v64-287

 

出版商: NRC Research Press

 

数据来源: NRC

 

摘要:

Evidence has been presented for the transient formation of a dienone-imine intermediate in the Fischer indole synthesis analogous to the dienone intermediate found in the Claisen rearrangement. The isolation of methylamine hydrochloride, 8-chloro-1,2,3,4-tetrahydrocarbazole, and 5-amino-6-chloro-9-methyl-1,2,3,4-tetrahydrocarbazole from the room temperature, uncatalyzed condensation between cyclohexanone and N′-methyl-2,6-dichlorophenylhydrazine under enamine synthesis conditions can be rationalized only on the assumption of the occurrence of a dienone-imine intermediate. An example of a facile, uncatalyzed Fischer cyclization at room temperature has been described.

 

点击下载:  PDF (381KB)



返 回