Acute Oral Captopril Inhibits Angiotensin Converting Enzyme Activity in Human Cerebrospinal Fluid
作者:
Pierangelo Geppetti,
Maria Spillantini,
Stefania Frilli,
Umberto Pietrini,
Marcello Fanciullacci,
Federigo Sicuteri,
期刊:
Journal of Hypertension
(OVID Available online 1987)
卷期:
Volume 5,
issue 2
页码: 151-154
ISSN:0263-6352
年代: 1987
出版商: OVID
关键词: Captopril;angiotensin converting enzyme (kininase II);human cerebrospinal fluid;enkephalinase
数据来源: OVID
摘要:
Angiotensin converting enzyme (ACE) activity in human plasma and cerebrospinal fluid (CSF), was measured by a fluorimetric method, following an acute oral dose (75 mg) of captopril. A decrease of approximately 60% in enzyme activity was observed in CSF, suggesting that the drug penetrates the blood/brain barrier (BBB) in sufficient amounts to inhibit the ACE in CSF. The activity of CSF enkephalinase, an enzyme present in human brain and inhibited invitroby an elevated concentration of captopril, was, however, unaffected by the acute drug administration. It is proposed that the antihypertensive effect of captopril in humans may be due, at least in part, to the inhibition of ACE contained within brain structures.
点击下载:
PDF
(348KB)
返 回