Marrow Histomorphology and Clinical Staging of Chronic Lymphocytic Leukemia-A Rare Disease in India: Experience with 26 Cases
作者:
SinghTejinder,
BasuDebdatta,
PrakashShashi,
RaniSudha,
GaihaManorama,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 10,
issue 1-2
页码: 117-119
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309147364
出版商: Taylor&Francis
关键词: Chronic lymphocyte leukemia;bone marrow biopsy
数据来源: Taylor
摘要:
Chronic Lymphocytic Leukemia is a relatively uncommon hemopoietic malignancy in the Indian subcontinent. We have made an attempt to correlate the morphology of the marrow with staging and clinical course of the disease in 26 cases. Four out of 6 cases in Stage A showed a nodular/interstitial marrow pattern, while 18 out of 20 cases of stage B and C demonstrated a mixed/diffuse involvement of marrow. Cases showing a nodular/interstitial pattern had a relatively benign clinical course even without chemotherapy, while patients with diffuse/mixed marrow pattern required chemotherapy. Trephine histological pattern was found to be a good prognosticator and was useful in segregating cases requiring chemotherapy from those which do not.
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