Some Physico-Chemical and Biological Properties of Triazeno Sugars
作者:
JeanM. J. Tronchet,
Françoise Barbalat-Rey,
JeannineF. Tronchet,
Faranak Raehidzadeh,
期刊:
Journal of Carbohydrate Chemistry
(Taylor Available online 1985)
卷期:
Volume 4,
issue 2
页码: 193-204
ISSN:0732-8303
年代: 1985
DOI:10.1080/07328308508058831
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Replacement of the alkyl group of l-aryl-3-alkyltriazenes with a sugar moiety did not significantly modify their tautomeric behaviour. The same replacement done on 1-aryl-3-alkyl-3-methyl-triazenes did not affect to any large extent their rotameric properties. In contrast, the most prominent biological properties, anticancer activity and toxicity, of 1-aryl-3-methyltria-zenes disappeared on replacement of the methyl group with a sugar moiety. Unexpectedly, the N-acetyltriazene 15 was highly cyto-toxic.
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