The analgesic and anti- inflammatory efficacy of diflunisal and Codeine after removal of impacted third molars
作者:
Kølsen PetersenJens,
期刊:
Current Medical Research and Opinion
(Taylor Available online 1978)
卷期:
Volume 5,
issue 7
页码: 525-535
ISSN:0300-7995
年代: 1978
DOI:10.1185/03007997809108996
出版商: Taylor&Francis
关键词: Diflunisal;codeine;pain;post-operative;tooth;impacted
数据来源: Taylor
摘要:
SummaryA double-blind, randomized trial was carried out in 90 patients to compare the analgesic and anti-inflammatory efficacy of 500 mg diflunisal twice daily with that of 25 mg codeine phosphate 4-times daily and of placebo in relieving pain and swelling after surgical removal of impacted third molars. Diflunisal was found to be superior to codeine and placebo on the first post-operative day, but the difference in efficacy of the drugs had diminished by the third post-operative day. In the diflunisal group of 30 patients, 10 (33%) developed‘dry socket’or alveolitis sicca dolorosa. Only 2 patients in the codeine group and 1 patient in the placebo group developed this very painful condition. The possible explanation of‘dry socket’is discussed.
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