Rivanol treatment of cystic fibrosis serum: effect of supernatant upon ciliary action
作者:
Michael L. McCombs,
Barbara H. Bowman,
期刊:
Clinical Genetics
(WILEY Available online 1970)
卷期:
Volume 1,
issue 3‐4
页码: 171-176
ISSN:0009-9163
年代: 1970
DOI:10.1111/j.1399-0004.1970.tb01633.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Serum from cystic fibrosis patients and their parents will inhibit ciliary movement on oyster gill tissue. Previous studies have indicated the factor responsible for ciliary inhibition is a cationic protein with a molecular weight between 125,000 to 200,000, and has properties similar to γG‐globulin. To support this evidence, sera from CF patients, heterozygotes, and control individuals were subjected to rivanol precipitation and the supernatants tested on oyster cilia. In addition other sources of cilia and flagella were examined as possible assay systems for the CF fact
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