Modulation of Hippocampal Glucocorticoid and Mineralocorticoid Receptor mRNA Expression by Amygdaloid Kindling
作者:
Mike Clark,
Mark A. Smith,
Susan R.B. Weiss,
Robert M. Post,
期刊:
Neuroendocrinology
(Karger Available online 1994)
卷期:
Volume 59,
issue 5
页码: 451-456
ISSN:0028-3835
年代: 1994
DOI:10.1159/000126691
出版商: S. Karger AG
关键词: Glucocorticoid receptor;Hippocampus;Kindling;Messenger RNA;Mineralocorticoid receptor;Seizure
数据来源: Karger
摘要:
In situ hybridization was used to examine the effects of amygdala kindling on the expression of mRNAs for mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the rat hippocampus. Kindling increased MR mRNA levels in the dentate gyms of the hippocampus 4 h after the last seizure, and these levels remained elevated 24 h later, but returned to baseline at 4 days. The only other hippocampal region that showed changes was the ipsilateral CA2 subfield where MR mRNA was significantly increased only at the 4-hour time point. Kindling also increased the levels of GR mRNA in the dentate gyms at 4 h; however, GR mRNA levels significantly decreased below control values at 24 h before returning to normal at 4 days. These data indicate differential transient alterations in hippocampal MR and GR receptor mRNA expression following amygdala-kindled seizures.
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