Aging effects of vitamin C on a human lens protein produced in vitro
作者:
Paul Russell,
Donita Garland,
J. Samuel Zigler,
Susan O. Meakin,
Lap‐Chee Tsui,
Martin L. Breitman,
期刊:
The FASEB Journal
(WILEY Available online 1987)
卷期:
Volume 1,
issue 1
页码: 32-35
ISSN:0892-6638
年代: 1987
DOI:10.1096/fasebj.1.1.3301496
出版商: Wiley
数据来源: WILEY
摘要:
Human lens γ‐crystallin obtained from the expression of a gene construct stably integrated into mouse L cells was incubated with ascorbate in the presence of iron and oxygen. The resulting oxidation of the γ‐crystallin led to more acidic species of this protein. These alterations were similar to the changes seen with aging in the human lens. The results suggest that oxidation of lens crystallins may be responsible for the changes seen on aging and cataract development and that ascorbate may contribute to these alterations.— Russell, P.; Garland, D; Zigler, J. S., Jr.; Meakin, S. O.; Tsui, L.‐C.; Breitman, M. L. Aging effects of vitamin C on a human lens protein produced in vitro.FASEB J.1: 32‐35; 1987.
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