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PEPTIDE SYNTHESIS WITH CARBODIIMIDE.

 

作者: J. Rebek,   D. Feitler,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1975）
卷期: Volume 7, issue 2  

页码: 167-169

 

ISSN:0367-8377

 

年代: 1975

 

DOI:10.1111/j.1399-3011.1975.tb02428.x

 

出版商: Blackwell Publishing Ltd

 

数据来源: WILEY

 

摘要:

An isotope dilution assay for racemization during acid couplings is described and applied to carbodiimide‐mediated synthesis. Using the coupling of t‐BOC‐L‐phenylalanine with glycine derivatives as a model, racemization in solution falls in the 0.01 to 0.1% range and is a function of reagent concentrations. A typical coupling using the solid phase method shows 0.03% r

 

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