Immunosuppressive Effect of Uterine Fluid on Spermatozoa-Stimulated Mixed Lymphocyte Cultures
作者:
R. Halperin,
S. Peller,
D. Schneider,
E. Hadas,
I. Bukovsky,
E. Caspi,
Y.` Soffer,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1996)
卷期:
Volume 41,
issue 2
页码: 118-121
ISSN:0378-7346
年代: 1996
DOI:10.1159/000292055
出版商: S. Karger AG
关键词: Spermatozoa;Mixed lymphocyte culture;Uterine fluid;Immunoglobulin G;Immunosuppression
数据来源: Karger
摘要:
Spermatozoa, obtained from 20 healthy individuals, were incubated with crude uterine fluid or with a purified IgG fraction obtained from uterine fluid before adding them to cultures with allogeneic lymphocytes. Untreated spermatozoa induced a proliferative 1.5- to 6-fold increase, while the spermatozoa treated with crude uterine fluid or with purified IgG fraction caused 84–100% suppression of lymphocyte blastogenesis. These results suggest the existence of an endogenous uterine fluid factor, apparently IgG, which causes inhibition of lymphocyte proliferation induced by spermatozoa in the uterine lume
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