Maturational changes in renal tubular transport
作者:
Michel Baum,
Raymond Quigley,
Lisa Satlin,
期刊:
Current Opinion in Nephrology and Hypertension
(OVID Available online 2003)
卷期:
Volume 12,
issue 5
页码: 521-526
ISSN:1062-4821
年代: 2003
出版商: OVID
关键词: transport;tubule;developmental nephrology;kidney
数据来源: OVID
摘要:
Purpose of reviewThis review examines the maturational changes that occur in renal tubules during postnatal development.Recent findingsThe ability to study transport in neonatal tubules and the use of molecular techniques have allowed studies that not only examine the mechanism of solute and water transport in neonates but also what causes the maturational changes in transport at a molecular and cellular level.SummaryThis review demonstrates that there are significant quantitative and qualitative differences in transport during postnatal maturation in every nephron segment. In some segments the maturational changes involve simply a change in abundance of transporters, while in others the difference in transport is due to changes in transporter isoforms, changes in paracellular permeability or changes in intracellular signaling that regulate the transporter. This review focuses on these changes and what is known about what causes the maturational changes in transport.
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