The Effect of Sodium Perchlorate and Ionizing Irradiation on the Thyroid Parenchymal and Pituitary Thyrotropic Cells
作者:
Zdenka Pajer,
Miroslav Kališnik,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 4
页码: 317-320
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226950
出版商: S. Karger AG
关键词: Thyroid parenchymal cells;Pituitary thyrotropic cells;Sodium perchlorate;Irradiation;Stereology
数据来源: Karger
摘要:
In a 46-week-experiment on 72 female mice the influence of peroral 1.2% sodium perchlorate application, total ionizing irradiation with 8 Gy on 5 consecutive days and their interaction on the pituitary-thyroid axis was studied by histological and stereological methods. It was observed that perchlorate alone caused long-term and strong hypothyroidism with hypertrophic and hyperplastic thyroid epithelial cells as well as pituitary thyrotropic cells. When only irradiation was used, no uniform changes in the structure and function of these cells could be detected. The interaction of perchlorate and irradiation showed similar effects as thyrostatics alone, with some exceptions; paradoxically, minor hyperplasia of thyrotropic as well as of parafollicular cells was observed. A high percentage of the follicular cell carcinoma was found after perchlorate application and after its combination with irradiation. No medullary carcinoma was found.
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