In vitroandin vivoActivity of 3-(1-Methyl 1-5-Nitro-2 Imidazolylmethylideneamino)-2-OxazoIidinone againstPasteurella
作者:
Bettina M. Frost,
Mary E. Valiant,
Eugene L. Dulaney,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 5
页码: 324-330
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221940
出版商: S. Karger AG
关键词: Pasteurella;Nitroimidazole;Furazolidone;Sulfaquinoxaline;in vitroactivity;in vivoactivity
数据来源: Karger
摘要:
Furazolidone was more active than 3-(1-methyl)-5-nitro-2-imidazolyl-methylideneamino)-2-oxazolidinone (MABN) against a series of 34 isolates of Pasteurella and 11 of Yersinia (formerly designated Pasteurella). However, the nitroimidazole was superior to furazolidone by both subcutaneous and oral routes against a series of mouse infections incited by strains of Pasteurella. It also was superior to furazolidone and sulfaquinoxaline when administered in the diet against two Pasteurella strains in a fowl cholera model infection in chickens. The good in vitro activity of MABN plus its low toxicity suggest its further study as an agent for fowl cholera and the shipping fever complex of cattle.
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