Immunohistochemical localization of redox factor‐1 (Ref‐1) in Alzheimer's hippocampus
作者:
Zhiqun Tan,
Ning Sun,
Steven Schreiber,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2749-2752
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Alzheimer's disease;Hippocampus;Immunohistochemistry;Neuronal apoptosis;Oxidative stress;Redox factor
数据来源: OVID
摘要:
REDOX factor-1 (Ref-1) is a dual-function protein involved in both DNA repair and transcriptional regulation. Ref-1 is modulated by cerebral ischemia and other oxidative stressors, and also regulates the DNA-binding activities of transcription factors implicated in Alzheimer's disease (AD)-related neurodegeneration. The present study examined Ref-1 expression in the AD hippocampus by immunohistochemistry. Although Ref-1 immunostaining was relatively low in control brain sections, senile plaques and other plaque-like structures in the AD brain were Ref-1-positive. Cells with increased Ref-1 immunoreactivity were also observed in regions of neuronal injury. These results suggest that Ref-1 might contribute to senile plaque formation, and that over-expression of Ref-1 in injured neurons may be part of a response to oxidative stress and an attempt to repair damaged DNA in AD.
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