Evidence that Serotonin Is Involved in Prolactin Release by Electrical Stimulation of the Medial Basal Hypothalamus in the Rhesus Monkey
作者:
K. Pavasuthipaisit,
R.L. Norman,
H.G. Spies,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 31,
issue 4
页码: 256-260
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123084
出版商: S. Karger AG
关键词: Prolactin;Electrical stimulation;Medial basal hypothalamus;Thyrotropin-releasing hormone;Methysergide;Bromocriptine;Rhesus monkey
数据来源: Karger
摘要:
The possibility that serotonin plays a role in prolactin secretion after electrical stimulation of the rhesus medial basal hypothalamus (MBH) was investigated. Prolactin responses to electrical stimulation and intravenous injection of 0.5 and 1.0 µg of thyrotropin-releasing hormone (TRH) were evaluated before and after administration of methysergide (MES), a serotonin receptor blocker (2 mg orally every 12 h for 48 h), and bromocriptine (CB-154), a dopamine agonist (2.5 mg orally every 12 h for 48 h). Both electrical stimulation and TRH caused prompt increases in serum prolactin. Prestimulation (basal) prolactin levels in both drug-treated groups were not significantly lower than basal levels in control groups. Pretreatment with MES significantly attenuated the electrically induced release of prolactin but had no effect on the TRH-induced release; CB-154 blocked prolactin release induced by both types of stimulation. The study reported here has provided evidence of a possible role for hypothalamic serotonin in releasing pituitary prolactin
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