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Optimizing Treatment Outcomes in Severe Community-Acquired Pneumonia

 

作者: Felipe Rodriguezdecastro,   Antoni Torres,  

 

期刊: American Journal of Respiratory Medicine  (ADIS Available online 2003)
卷期: Volume 2, issue 1  

页码: 39-54

 

ISSN:1175-6365

 

年代: 2003

 

出版商: ADIS

 

关键词: Antibacterials, therapeutic use;Community acquired pneumonia, treatment;Immunomodulators, therapeutic use;Mechanical ventilation

 

数据来源: ADIS

 

摘要:

Severe community-acquired pneumonia (CAP) is a life-threatening condition that requires intensive care unit (ICU) admission. Clinical presentation is characterized by the presence of respiratory failure, severe sepsis, or septic shock. Severe CAP accounts for approximately 5−35% of hospital-treated cases of pneumonia with the majority of patients having underlying comorbidities. The most common pathogens associated with this disease areStreptococcus pneumoniae,Legionellaspp.,Haemophilus influenzae, and Gram-negative enteric rods.Microbial investigation is probably helpful in the individual case but is likely to be more useful for defining local antimicrobial policies. The early and rapid initiation of empiric antimicrobial treatment is critical for a favorable outcome. It should include intravenous β-lactam along with either a macrolide or a fluoroquinolone. Modifications of this basic regimen should be considered in the presence of distinct comorbid conditions and risk factors for specific pathogens. Other promising nonantimicrobial new therapies are currently being investigated.The assessment of severity of CAP helps physicians to identify patients who could be managed safely in an ambulatory setting. It may also play a crucial role in decisions about length of hospital stay and time of switching to oral antimicrobial therapy in different groups at risk. The most important adverse prognostic factors include advancing age, male sex, poor health of patient, acute respiratory failure, severe sepsis, septic shock, progressive radiographic course, bacteremia, signs of disease progression within the first 48−72 hours, and the presence of several different pathogens such asS. pneumoniae,Staphylococcus aureus, Gram-negative enteric bacilli, orPseudomonas aeruginosa. However, some important topics of severity assessment remain controversial, including the definition of severe CAP. Prediction rules for complications or death from CAP, although far from perfect, should identify the majority of patients with severe CAP and be used to support decision-making by the physician. They may also contribute to the evaluation of processes and outcomes of care for patients with CAP.

 

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