Effects of Combined Clomiphene Citrate and Exogenous Oestrogen or Progesterone on the Vaginal Epithelium of Ovariectomised Rats
作者:
V. Terry,
C.R. Murphy,
C.D. Shorey,
期刊:
Cells Tissues Organs
(Karger Available online 1995)
卷期:
Volume 152,
issue 1
页码: 11-18
ISSN:1422-6405
年代: 1995
DOI:10.1159/000147678
出版商: S. Karger AG
关键词: Vagina;Vaginal Epithelium;Clomiphene citrate;Oestrogen;Rat
数据来源: Karger
摘要:
The interactive effects of clomiphene citrate (CC) and exogenous oestrogen (E2) or progesterone (P4), on the vaginal epithelium of ovariectomised rats were examined using scanning electron microscopy and light microscopy. Results were compared with P4E2 treatment. Statistical analysis showed no significant difference between the two combination CC treatments. All treatment groups had the ability to stimulate a dormant epithelium and cause surface modifications in the form of individually elongated microvilli and rosette formations. The results of this study indicate that v/hile P4 enhances the oestrogenicity of CC, there is no cumulative oestrogenic effect when E2 and CC are combined, but there is modification of cell surface organisation and evidence of anti-oestrogenic activity.
点击下载:
PDF
(1380KB)
返 回