Trajectories of regenerating retinal axons in the goldfish tectum: I. A comparison of normal and regenerated axons at late regeneration stages
作者:
Claudia A. O. Stuermer,
期刊:
Journal of Comparative Neurology
(WILEY Available online 1988)
卷期:
Volume 267,
issue 1
页码: 55-68
ISSN:0092-7317
年代: 1988
DOI:10.1002/cne.902670105
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: retinotectal projection;abnormal paths;HRP anterograde staining;tectal whole mounts
数据来源: WILEY
摘要:
AbstractTo visualize and compare the intratectal path of normal and regenerated retinal axons, HRP was applied to localized sites in the dorsotemporal and dorsonasal retina in normal goldfish and in goldfish at 3–12 months after optic nerve section. The anterogradely labeled axons were traced in tectal whole mounts.In normal animals the axons were confined to the appropriate ventral hemitectum. Therein they ran in very orderly routes (Stuermer and Easter:J. Neurosci. 4:1045–1051, '84) and terminated in regions retinotopic to the labeled ganglion cells in the retina. The terminal arbors of dorsotemporal axons resided in the ventrocaudal tectum and those of dorsonasal axons in the ventrocaudal tectum.In regenerating animals the terminal arbors also resided at retinotopic regions, where they sometimes formed two separate clusters. In contrast to normal axons, the regenerating ones traveled in abnormal routes through the appropriate and inappropriate hemitectum. From various ectopic positions, they underwent course corrections to redirect their routes toward the retinotopic target region. In their approach toward their target sites, dorsotemporal and dorsonasal axons behaved differently in that the vast majority of dorsotemporal axons coursed over the more rostral tectum whereas dorsonasal axons progressed into the caudal tectal half.This differential behavior of regenerating dorsonasal and dorsotemporal axons was substantiated by a quantitative evaluation of axon numbers and orientati
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