Immunoglobulin-E-Specific Suppressor Factors in Primary Glomerulonephritis with Nephrotic Syndrome
作者:
Kuo-hsiung Shu,
Jong-da Lian,
Yuan-san Lu,
Chi-hung Chen,
Duu-yih Tsai,
Kai-shen Chao,
Wen-iuan Chiu,
Shen-huey Lee,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 60,
issue 4
页码: 432-435
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186804
出版商: S. Karger AG
关键词: Immunoglobulin-E;Immunoglobulin-E-binding factors;Primary glomerulonephritis
数据来源: Karger
摘要:
Human immunoglobulin (Ig) E synthesis is regulated by T-cell-derived binding factors which include potentiating factors and suppressor factors (IgE-SFs) and B-cell-derived factors. Seventeen cases of primary glomerulonephritis (GN) with nephrotic syndrome and high serum IgE were studied for their serum IgE-SFs. These include 8 cases of minimal-change disease (MCD), 3 cases of IgM nephropathy, 4 cases of focal segmental glomerulosclerosis, and 2 cases of IgA nephropathy, aged between 20 and 60 years (mean: 37.2). A significantly lower activity of these factors was noted in the patient group as shown by a lower overall inhibition rate on in vitro IgE synthesis (median: 22.9 vs. 53.2%, p < 0.05). Some of them even exhibited an enhancing activity in their serum as shown by a negative inhibition rate. These findings suggest that there is a T cell disorder in some of the primary GNs with high serum IgE, especially in MCD, which causes an abnormal regulation of IgE synthesis.
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