首页   按字顺浏览 期刊浏览 卷期浏览 Immunological Effects of Recombinant Interferon‐α2in Cancer Patients
Immunological Effects of Recombinant Interferon‐α2in Cancer Patients

 

作者: James Hengst,   Raymond Kempf,   June Kan-Mitchell,   Anh Pham,   Steven Grunberg,   Virginia Kortes,   Malcolm Mitchell,  

 

期刊: Journal of Biological Response Modifiers  (OVID Available online 1983)
卷期: Volume 2, issue 6  

页码: 516-527

 

ISSN:0732-6580

 

年代: 1983

 

出版商: OVID

 

关键词: Antibody-dependent cellular cytotoxicity;Interferon-α2;Monocyte-mediated cytotoxicity;Natural killing

 

数据来源: OVID

 

摘要:

SummaryFifteen patients with various types of cancer, resistant to conventional therapy, were entered into a phase I trial of pure interferon-α2(IFN-α2) produced by recombinant DNA technology. Groups of patients received either 3, 10, 30, or 50 X 106units (U) of IFN-α2subcutaneously daily for 4 weeks and were closely followed for possible toxicity. At the higher doses, toxicity was encountered, which led to reduction in the frequency of administration. For immunological testing, peripheral blood mononuclear cells were obtained before treatment on day 1, on day 2, and during the 2nd, 3rd, and 7th weeks of the study. The cells were tested for natural killer (NK) activity, antibody-dependent cellular cytotoxicity (ADCC), monocyte-mediated antibody-dependent cellular cytotoxicity (MMADCC), and spontaneous monocyte-mediated cytotoxicity (SMC). ADCC was augmented at all doses in 9 of 15 patients, 6 of whom exhibited elevated levels by day 2. In direct contrast, MMADCC was decreased in 12 of 14 patients 7–20 days after beginning treatment. SMC was increased on day 2 in 1 of 2 patients given 3 X 106U and in 3 of 4 patients given 10 X 106U. SMC in the other patients given these doses was unchanged on day 2, with no decreases noted. In contrast, SMC was decreased in 2 of 4 patients given 30 X 106U and in 2 of 3 patients given 50 X 106U. NK cell activity was increased in 2 of 3 patients given 3 X 106U, but was either unchanged or decreased in patients given higher doses. The only exception was an increase found in a patient given 50 X 106U, whose renal cell carcinoma responded significantly to treatment. Data on NK and SMC from a phase II study of breast cancer treated daily with 3 X 106U IFN-α2support our phase I observations. NK-cell activity was increased on day 2 in 3 of 8 patients, and SMC increased in 2 of 8 patients. As in the phase I study, no decreases in these functions occurred. In summary, for those responses that were dose dependent, such as NK and SMC, lower doses of recombinant IFN-α2(3 X 106and possibly 10 X 106U) may be more effective in increasing these anti-tumor activities than are higher doses.

 

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