Experimental Selenium Toxicity in Guinea Pigs: Biochemical Studies
作者:
P.M. Das,
J.R. Sadana,
Paul Gupta,
K. Kumar,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1989)
卷期:
Volume 33,
issue 1
页码: 57-63
ISSN:0250-6807
年代: 1989
DOI:10.1159/000177521
出版商: S. Karger AG
关键词: Sodium arsenite;Barley;Glutathione peroxidase;Selenium;Biochemical changes
数据来源: Karger
摘要:
Biochemical studies were conducted in experimentally induced selenium toxicity in recently weaned guinea pigs. A significant drop in blood glucose level, in comparison to controls, was observed in animals fed selenium-enriched barley (organic form) as well as those fed ordinary barley mixed with sodium selenite (inorganic form). Estimation of total serum proteins also revealed a significant drop in both these groups. SGOT (EC 2.6.1.1) activity was comparatively lower but no significant alteration was noticed in SGPT (EC 2.6.1.2). The erythrocytic glutathione peroxidase activity was significantly increased in inorganic selenosis followed by that in organic one, in comparison to controls. All these alterations were of mild degree in guinea pigs which were given sodium arsenite (10 ppm) along with sodium selenite (30 ppm) in the feed.
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