Effect of Intraventricular Glutamate on ACTH Release
作者:
G.B. Makara,
E. Stark,
期刊:
Neuroendocrinology
(Karger Available online 1975)
卷期:
Volume 18,
issue 2
页码: 213-216
ISSN:0028-3835
年代: 1975
DOI:10.1159/000122400
出版商: S. Karger AG
关键词: Glutamate;ACTH release
数据来源: Karger
摘要:
Sodium glutamate infused into the 3rd ventricle is a potent stimulus of ACTH release, as shown by the rise in plasma corticosterone levels. Glutamate failed to consistently increase the plasma corticosterone level in rats with deafferentation of the medial basal hypothalamus (MBH). We suggest that intraventricular glutamate interferes with central nervous function outside the MBH and stimulates ACTH release via afferent neural pathways.
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