Toxic Congener-Specific Analysis of PCBs: Assessment of Toxicity in Equivalents of TCDD
作者:
P.G. Olafsson,
A.M. Bryan,
期刊:
Analytical Letters
(Taylor Available online 1987)
卷期:
Volume 20,
issue 11
页码: 1719-1727
ISSN:0003-2719
年代: 1987
DOI:10.1080/00032718708082590
出版商: Taylor & Francis Group
关键词: High Resolution G. C.;TCDD Equivalents;Aryl Hydrocarbon Hydroxylase;Bioassay
数据来源: Taylor
摘要:
High resolution capillary gas chromatographic analysis of the polychlorobiphenyls (PCBs) present in snapping turtle eggs, provided quantitative data on selected toxic congeners. The concentrations of these congeners have been converted into equivalent toxic concentrations of 2,3,7,8-tetrachloro-p-dibenzodioxin (TCDD). The toxic equivalent factors (TEFs), necessary to effect this transformation were derived from EC50values (half the concentration of the toxic congener required to produce the maximum effect) for aryl hydrocarbon hydroxylase (AHH) induction associated with the corresponding toxic PCB congener or isomer. Summation of the resulting toxic equivalents provided a composite assessment of the toxlcity of the PCB mixture in terms of an equivalent concentration of TCDD.
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