Methionine Metabolism in Pyridoxine Deficiency
作者:
Kamala Krishnaswamy,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1974)
卷期:
Volume 17,
issue 1
页码: 55-63
ISSN:0250-6807
年代: 1974
DOI:10.1159/000175518
出版商: S. Karger AG
关键词: Methionine;Peripheral neuropathy;Pyridoxine;Cystathioninuria;Transaminase
数据来源: Karger
摘要:
Methionine metabolism was studied in a group of subjects having clinical signs and symptoms of peripheral neuropathy. Following a load of methionine, these subjects excreted higher amounts of cystathionine, and the ratio of cystathionine/ cysteine sulfinic acid was elevated suggesting a block in the conversion of cystathionine to cysteine sulfinic acid. The load return of methionine as cystathionine was significantly more. These results indicate that the activity of enzyme cystathionase, a pyridoxal-dependant enzyme, is low in pyridoxine deficiency. With pyridoxine therapy, there was a significant improvement in the clinical status, and the biochemical abnormalities were corrected.
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