Blood Levels of Haloperidol in Schizophrenic Patients
作者:
ALLA SHVARTSBURD,
HAROUTUNE DEKIRMENJIAN,
ROBERT SMITH,
期刊:
Journal of Clinical Psychopharmacology
(OVID Available online 1983)
卷期:
Volume 3,
issue 1
页码: 7-12
ISSN:0271-0749
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
Plasma and red blood cell levels of haloperidol were measured in psychotic patients after an acute dose of haloperiodol and during treatment with fixed doses for several weeks. There was wide variability of haloperidol plasma and red blood cell levels at a given dose and a nonlinear relationship between haloperidol dose and blood levels. The red blood cell/plasma ratio (0.40) had a narrow range among different patients. Haloperidol blood levels were not correlated with the age of the patient. Concomitant administration of benztropine mesylate did not decrease plasma haloperidol levels. Steady state plasma or red cell haloperidol levels could not be predicted from levels 24 hours after the acute dose.
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