Neuropeptide Y and somatostatin inhibit stimulated cyclic AMP production in rabbit ciliary processes
作者:
BausherLarry P.,
HorioBlake,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 4
页码: 371-378
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999625
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The interaction of adrenergic and peptide receptors linked to adenylate cyclase and the inhibition by bioactive peptides of stimulated cyclic AMP production has been investigated in intact, excised rabbit ciliary processes. Cyclic AMP production stimulated by isoproterenol, vasoactive intestinal peptide, or forskolin was inhibited by the biologically active peptides neuropeptide Y, somatostatin, and the synthetic somatostatin analogue SMS 201-995. IC508 determined from dose-response curves of inhibition are consistent with the known abilities of these ligands to modulate cyclic AMP and physiological responses in other tissues. Inhibition by neuropeptide Y or SMS 201-995 was unaffected by the specific alpha2-adrenergic antagonist yohimbine, which shows that peptide inhibition is not occurring via peptide binding to the inhibitory alpha2-adrenergic receptor. These results suggest that endogenous peptides may participate in modulation of cyclic AMP production and subsequent physiological events influenced by cyclic AMP levels in rabbit ciliary processes by inhibiting stimulated cyclic AMP synthesis.
点击下载:
PDF (605KB)
返 回