Die Wirkung einer Unterbrechung der Dottersackzirkulation auf die Ultrastruktur des Dottersacks und die Entwicklung des Fetus bei der Ratte
作者:
H. Franke,
期刊:
Cells Tissues Organs
(Karger Available online 1979)
卷期:
Volume 103,
issue 2
页码: 200-211
ISSN:1422-6405
年代: 1979
DOI:10.1159/000145011
出版商: S. Karger AG
关键词: Vitelline circulation;Yolk sac ischaemia;Rat fetus;Development;Rat visceral yolk sac
数据来源: Karger
摘要:
The effect of an interruption of the yolk sac circulation on the rat visceral yolk sac and the development of the fetoplacental unit was examined in the last third of pregnancy. The yolk sac ischaemia was induced by ligating the blood vessels of the yolk sac stalk which connect the vitelline circulation with that of the fetus. A 3-hour ligature caused an extensive swelling of most cell organelles in the epithelial cells and in the capillary endothelia of the yolk sac. Other structural changes were indicative of a cessation of pinocytosis. A 6-hour ligature resulted in a common ncrease of cell swelling and in a beginning disintegration of the endothelial cells lining the vitelline capillaries. A 15-hour ligature caused severe ultrastructural cell lesions and macroscopical alterations suggestive of a progressive necrosis of the entire yolk sac tissue. Of special significance was the regular finding of a nearly complete loss of the amniotic fluid and the death of the fetus, although the maternal blood flow appeared to be still intact in the placenta.
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