Effect of change of fecal bile acid excretion achieved by operative procedures on 1,2‐dimethylhydrazine‐induced colon cancer in rats
作者:
Krisztina Morvay,
Károly Szentléleki,
Géza Török,
Alan Pintér,
Mátyás Börzsönyi,
Reinhard Nawroth,
期刊:
Diseases of the Colon & Rectum
(OVID Available online 1989)
卷期:
Volume 32,
issue 10
页码: 860-863
ISSN:0012-3706
年代: 1989
出版商: OVID
关键词: Colonic cancer;Bile acid;1,2‐Dimethylhydrazine;Rats
数据来源: OVID
摘要:
&NA;The effect of bile on the development of 1,2‐dimethylhydrazine (DMH)‐induced colon cancer was studied in male Wistar rats. Experimental operative models were created, in which in Group 1, the half intestinal tract, the ileum, and the right side of colon were released from bile. In Group 2, both sides of the colon contained bile. The sham operated animals formed Group 3. These techniques changed the concentration of bile acid in different parts of the colon, and the daily total fecal bile acid excretion as well. After DMH treatment, the relationship between these changes of bile acid level and the development of colon cancer was studied. Significantly more tumors than in the control group were found if the daily total bile acid level and the bile acid concentration in the left side of the colon were increased. Our findings show an unambiguous connection between the fecal bile acid level and the incidence of DMH‐induced colon cancer.
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