Interlaboratory Study of the Analysis of Amoxicillin by Liquid Chromatography
作者:
Zhu Yongxin,
E. Roets,
A. Bruzzi,
A.J. W. Smelt,
C. Van der Vlies,
P. Betto,
M.L. Moreno,
E. Porqueras,
H.H. Wendebourg,
K. Sinivuo,
D. De Kaste,
A. Mayrhofer,
N. Graby,
G. Kister,
J.H. McB Miller,
C.J. Nap,
J.M. Spieser,
J. Hoogmartens,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 1996)
卷期:
Volume 19,
issue 20
页码: 3305-3314
ISSN:1082-6076
年代: 1996
DOI:10.1080/10826079608014581
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A liquid chromatography method for analysis of amoxicillin was examined in a collaborative study involving 11 laboratories. The method comprised an isocratic part, which is used in the assay. The isocratic part is similar to the assay method for amoxicillin of the United States Pharmacopeia 23. When the isocratic part is combined with gradient elution, the method is suitable for purity control. Five samples of amoxicillin (trihydrate and sodium salt) with varying purity were analysed.
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