Transcription of the Genes Encoding the Small Heat Shock Protein Ubiquitin is Unchanged in Patients with Systemic Lupus Erythematosus
作者:
TwomeyBreda,
McCallumStuart,
DhillonVeena,
IsenbergDavid,
LatchmanDavid,
期刊:
Autoimmunity
(Taylor Available online 1992)
卷期:
Volume 13,
issue 3
页码: 197-200
ISSN:0891-6934
年代: 1992
DOI:10.3109/08916939209004824
出版商: Taylor&Francis
关键词: SLE;heat shock;transcription;ubiquitin
数据来源: Taylor
摘要:
The heal shock proteins hsp90 and hsp70 have been shown to be over-expressed in peripheral blood mono-nuclear cells from SLE patients. We show, however, that transcription of the three genes encoding the small hsp ubiquitin is not enhanced in these patients. The over expression of hsp90 and hsp70 in SLE is likely therefore to reflect cellular events resulting in the specific induction of these hsps rather than a generalized induction of all hsp synthesis due to the stress of the disease or the presence of fever.
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