In previously reported experiments we have shown that an intense sound exposure can temporarily depress the cochlear nerve evoked potential (N1) while not affecting the alternating current cochlear potential [J. Acoust. Soc. Am. S3, 326 (1973)]. Sodium salicylate was likewise found to produce a temporary effect on N1 only. In this experiment it was found that when these agents are given together they produced a greater change inN1than either agent alone, but not more than would be expected from a simple summation. This combined effect‐ of both agents onN1‐was also temporary. The interaction of these agents did not affect the ac cochlear potential. This interaction—of intense sound and sodium salicylate‐does not produce the permanent damaging interaction effects reported for other ototoxic drugs.