Long-Term Survivors in Resected and Nonresected Small Cell Lung Cancer
作者:
Nobuyuki Hara,
Yukito Ichinose,
Tomoharu Kuda,
Hiroshi Asoh,
Tokujiro Yano,
Masayuki Kawasaki,
Mitsuo Ohta,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 6
页码: 441-447
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226977
出版商: S. Karger AG
关键词: Small cell lung cancer;Resection;Long-term survival
数据来源: Karger
摘要:
Long-term survival (≥3 years) was evaluated in 164 patients with small cell lung cancer (SCLC). Thirty-seven patients underwent surgical resection, and 127 did not. All but one resected patient received combination chemotherapy. Of the 20 (12%) long-term survivors, 13 (35%) were resected, and 7 (6%) were not. Eleven of these resected patients had pathologically confirmed stage I disease. All of the 7 nonresected patients achieved complete remission by treatment, 6 of these having presented with limited disease. In addition, all patients received thoracic irradiation combined with chemotherapy. Two of the 20 patients who survived beyond 3 years developed a second malignancy 11.3 and 12 years, respectively, after initial treatment for SCLC. In conclusion, surgical resection for stage I, and probably stage II SCLC followed by chemotherapy may be an appropriate therapeutic approach. For advanced limited disease, thoracic irradiation, in addition to chemotherapy, seems to improve long-term surviva
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