Enhanced motor cortical excitability in the unaffected hemisphere after hemispherectomy
作者:
Toshio Shimizu,
Tadashi Nariai,
Taketoshi Maehara,
Taro Hino,
Tetsuo Komori,
Hiroyuki Shimizu,
Shunsaku Hirai,
Michio Senda,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 14
页码: 3077-3084
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Brain plasticity;Functional hemispherectomy;Ipsilateral motor response;Motor cortical excitability;PET;Transcranial magnetic stimulation
数据来源: OVID
摘要:
We evaluated motor cortical excitability of the unaffected hemisphere in three patients with intractable epilepsy who underwent hemispherectomy, using transcranial magnetic stimulation (TMS) and PET. TMS of the unaffected hemisphere evoked motor responses not only in the contralateral muscles but also in the ipsilateral ones in all the patients. A PET study in one patient showed activation of the unaffected motor cortex by movement of either arm. All of these responses were enhanced after the hemispherectomy, probably due to motor cortical disinhibition by transection of the corpus callosum. The PET study also showed postoperative activation of the premotor area of the unaffected hemisphere. These phenomena indicate posthemispherectomy neuroplastic reorganization leading to preservation of the motor function after the operation.
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