Profound inhibition of cardiomotor neurons in the rat rostral ventrolateral medulla by nociceptin (orphanin FQ)
作者:
Xiangping Chu,
Ningshan Xu,
Peng Li,
John Wang,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 6
页码: 1081-1084
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Blood pressure;Brain slice;Cardiovascular activity;Electrophysiology;Heart rate;Naloxone;Nociceptin;Orphanin FQ;Rostral ventrolateral medulla
数据来源: OVID
摘要:
Nociceptin (orphanin FQ), the newly discovered endogenous ligand for the opioid receptor like-1 receptor, profoundly inhibited spontaneous discharges of neurons in the rostral ventrolateral medulla (RVLM) in rat brain slices. This inhibition was concentration-dependent (0.3, 1, 3 and 10 nM) and insensitive to pharmacological blockade of traditional opioid receptors by naloxone. Moreover, nociceptin injected into the RVLM (10 nM, 0.1 μl) in anesthetized rats decreased arterial blood pressure and heart rate by 31% and 15%, respectively. The data obtainedin vitroandin vivosuggest that nociceptin has powerful effects on the RVLM neurons involving central control of cardiovascular activity. The negative regulation of cardiovascular activity by nociceptin is not mediated through typical naloxone-sensitive opioid receptors.
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