Interaction Between Digoxin and Propafenone
作者:
M.,
Calvo A.,
Martin-Suarez C,
Luengo C.,
Avila M.,
Cascon A.,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 1
页码: 10-15
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Digoxin;Propafenone;Drug interaction;Serum digoxin concentration;Monitoring.
数据来源: OVID
摘要:
The pharmacokinetic and pharmacodynamic interactions between digoxin and propafenone were investigated in 10 hospitalized patients with heart disease and cardiac arrhythmias. During steady state (0.25 mg/day) the glycoside was combined with 600 mg of propafenone daily for 1 week. The mean \pm SD serum digoxin concentration (SDC) was 0.97 \pm 0.29 ng/ml before and 1.54 \pm 0.65 ng/ml (p < 0.003) during propafenone administration. Propafenone induced a mean decrease in 31.1 and 31.7% in total and renal digoxin clearances, respectively. The increase in SDCs was accompanied by a decrease in heart rate (HR) and shortening of QTc(QT interval corrected for HR). In patients receiving digoxin and propafenone simultaneously, the SDCs should be monitored and the digoxin dose reduced if there is evidence of toxicity.
点击下载:
PDF
(395KB)
返 回