Lazaroid‐enhanced survival of grafted dopamine neurons does not increase target innervation
作者:
Lars Björklund,
Nina Vidal,
Ingrid Strömberg,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2815-2819
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Dopaminergic innervation;Graft;Lateral ganglionic eminence;Parkinson's disease;Ventral mesencephalon
数据来源: OVID
摘要:
THE lazaroid U-74006F enhances survival of grafted ventral mesencephalic neurons. In this study the intraocular grafting model was used and survival and outgrowth from fetal ventral mesencephalic grafts treated with U-74006F was evaluated in nigrostriatal co-grafts. Fetallateral ganglionic eminence was implanted into the anterior eye chamber and left to mature. Fetal ventral mesencephalon was then implanted and the eyes were treated with U-74006F. The lazaroid treatment enhanced survival of tyrosine hydroxylase (TH)-positive neurons, but did not enhance TH-positive nerve fiber growth into the striatal portions of the co-grafts. However, a marked increasein nerve fiber formation was found within the ventral mesencephalic grafts. Inconclusion, increased cell survival enhanced nerve fiber formation within the ventral mesencephalic portion of the co-graft and not, as expected, in the striatal part.
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