Hypercalcemia Reduces Renal Medullary Content of Organic Osmolytes
作者:
NakahamaHajime,
NakanishiTakeshi,
SugitaMinoru,
期刊:
Renal Failure
(Taylor Available online 1996)
卷期:
Volume 18,
issue 2
页码: 241-246
ISSN:0886-022X
年代: 1996
DOI:10.3109/08860229609052793
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Hypercalcemia is often associated with a urinary concentration defect. During antidiuresis, organic osmolytes [sorbitol, myo-inositol, taurine, and glycerophosphorylcholine (GPC)] accumulate in the renal inner medulla and are essential for urinary concentration. To clarify the relationship between organic osmolytes and urinary concentration defect in hypercalcemia, examination was made of the effects of hypercalcemia on renal medullary osmolytes content. Rats were put in a state of hypercalcemia by a calcium-rich diet supplemented with CaCO3(2.5%/wt) anddaily s.c. injection of I,25(OH)2VitD3(1.6μg/kg). They were killed on days 7 and 14. Hypercalcemia induced a urinary concentration defect. Myo-inositol, sorbitol, and GPC contents in the renal medulla were significantly reduced. Aldose reductase activity decreased significantly. Hypercalcemia would thus appear to directly affect renal medullary content of organic osmolytes, thereby modifying renal concentration ability.
点击下载:
PDF (339KB)
返 回