Optimal treatment of cancer diseases
作者:
ANDREAS NOVAK,
GUSTAV FEICHTINGER,
期刊:
International Journal of Systems Science
(Taylor Available online 1993)
卷期:
Volume 24,
issue 7
页码: 1253-1263
ISSN:0020-7721
年代: 1993
DOI:10.1080/00207729308949557
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A new optimal control model of chemotherapeutic cancer treatment is presented including both the number of cancer cells and the level of toxicity as state variables. It is shown that under certain conditions, periodic drug administration is optimal. Although the model is highly stylized and too simple to describe realistic chemotherapeutic treatment patterns, it may be seen as a first step to prove that periodic treatment strategies are superior to therapies with monotonic decreasing or increasing dosage rates.
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