On the chronobiology ofTetrahymena. II. Further evidence for the persistence of ultradian rhythmicity in the absence of protein synthesis and cell growth**
作者:
G. Thiel,
R. Hardeland,
U. Michel,
期刊:
Journal of Interdisciplinary Cycle Research
(Taylor Available online 1985)
卷期:
Volume 16,
issue 1
页码: 11-16
ISSN:0022-1945
年代: 1985
DOI:10.1080/09291018509359866
出版商: Taylor & Francis Group
关键词: Cell cycle;Tetrahymena;tyrosine aminotransferase;ultradian rhythms
数据来源: Taylor
摘要:
InTetrahymena thermophila, the ultradian rhythm of tyrosine aminotransferase activity was investigated under free‐running conditions. The rhythm persisted in the presence of 1 mM emetine, although the drug efficiently inhibited both protein synthesis and cell division. Also 250 mM hydroxyurea, which suppressed cell growth to a high degree, did not prevent the rhythm. These data support the concept of an ultradian oscillator working independently of translation and beingnota consequence of the “cell cycle”;, although under normal physiological conditions the rhythm of tyrosine aminotransferase is accompanied by and equiperiodic with the rhythm of cell division, both in the ultradian and circadian growth modes.
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