Gastrointestinal Necrosis in Acute Leukemia: A Complication of Induction Therapy
作者:
JonesG. Tripp,
AbramsonNeil,
期刊:
Cancer Investigation
(Taylor Available online 1983)
卷期:
Volume 1,
issue 4
页码: 315-320
ISSN:0735-7907
年代: 1983
DOI:10.3109/07357908309063294
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Gastrointestinal complications in acute leukemia have been infrequently reported. Reported here is a review of all patients on the hematology teaching service with acute leukemia from 1974 to 1980 and those with intestinal complications. Of the 50 patients with acute leukemia, 14 (28%) developed an acute abdominal catastrophe. They presented with an acute surgical abdomen, diarrhea, gastrointestinal bleeding, and a paralytic ileus. All were granulocytopenic and thrombocytopenic. All but one episode was associated with the death of the patients; survival ranged from 4 to 26 days (median 9 days) after their last dose of chemotherapeutic drugs. Cytarabine was administered in 13 of the 14 patients. It is believed that bowel necrosis which causes death in acute leukemia occurs more frequently than previously thought. There is a close association of the clinical syndrome with chemotherapeutic drugs, especially cytarabine.
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