Immunocytochemical Staining of Proliferating Cells in Endoscopically Biopsied Tissues of Gastric Carcinomas with Monoclonal Antibody Ki-67
作者:
Yutaka Yonemura,
Hironobu Kimura,
Shigekazu Ooyama,
Tom Kamata,
Akio Yamaguchi,
Hisashi Matsumoto,
Itasu Ninomiya,
Itsuo Miyazaki,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 2
页码: 162-165
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226918
出版商: S. Karger AG
关键词: Ki-67 monoclonal antibody;Proliferative activity;Gastric carcinoma
数据来源: Karger
摘要:
The growth fractions in endoscopically biopsied materials from 121 patients with gastric carcinomas were determined by immunohistochemical staining with the monoclonal antibody Ki-67 and the results correlated with the histopathologic findings and clinical outcome. The Ki-67 labeling rates ranged from 4.6 to 52% (mean: 22%). A significant correlation was found between Ki-67 labeling rates of biopsied materials and those of resected specimens. The tumors showing Ki-67 labeling rates of greater than 22% are more likely to have lymph node metastasis, lymphatic invasion or serosal invasion than those with the rates below 22%. In addition, Ki-67 labeling rates were closely associated with prognosis. Tumors with high Ki-67 labeling rates (greater than 22%) were related to poor prognosis, whereas those with low Ki-67 labeling rates were associated with favorable prognosis. The immunohistochemical staining of proliferating cells in endoscopically biopsied specimens of gastric carcinomas using the Ki-67 monoclonal antibody may be useful in assessing prognosis in carcinoma of the stomach.
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