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Taq I Polymorphism of the Epidermal Growth Factor Receptor Gene in Caucasoids and Japanese

 

作者: Merica Pavlovic,   Peter H. Kay,   Junko Moriuchi,   Philip F. Jacobsen,   John M. Papadimitriou,  

 

期刊: Human Heredity  (Karger Available online 1993)
卷期: Volume 43, issue 1  

页码: 39-44

 

ISSN:0001-5652

 

年代: 1993

 

DOI:10.1159/000154112

 

出版商: S. Karger AG

 

关键词: EGF receptor gene;Population studies;Restriction fragment length polymorphism;Tumorigenesis;Glioma

 

数据来源: Karger

 

摘要:

Genetic polymorphism of the epidermal growth factor (EGF) receptor gene following Taq I digestion was compared between samples of genomic DNA from glioma-derived cell lines and Caucasoid and Japanese subjects. The same three allelic forms of the EGF receptor gene, marked by variant fragments of approximately f 2.8, f 1.6 and f 0.8 kb in size were common to both ethnic groups and the 12.8- and 11.6-kb fragments were found in the glioma-derived cell line DNA. A further variant fragment of approximately 13.8 kb in size has been shown to be thus far restricted to the Japanese. These data suggest that most allelic forms of the EGF receptor gene recognized by Taq I restriction fragment length polymorphism have a long evolutionary history and probably do not predispose to development of malignant glioma.

 

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