The solvent extraction method of separating and purifying Na99mTcO4from low specific activity99Mo is rarely employed in developed countries, whereas in India Na99mTcO4has been separated, purified and used in an injectable form for the past decade using low specific activity99Mo and an indigenous separator system. The entire operation was previously carried out by a manual method. In order to decrease the radiation burden to the personnel performing these operations the process assembly was redesigned to incorporate additional safeguards against radiation. The paper decribes the modifications introduced and our experiences with this ‘semi-automated’ system.