Red Blood Cell Sodium Transport and Phosphate Release in Uremia
作者:
Udo Walter,
Eduard Becht,
期刊:
Nephron
(Karger Available online 1983)
卷期:
Volume 34,
issue 1
页码: 35-41
ISSN:1660-8151
年代: 1983
DOI:10.1159/000182975
出版商: S. Karger AG
关键词: Uremia;Erythrocyte electrolytes;Sodium efflux;Phosphate release;Ouabain
数据来源: Karger
摘要:
Red blood cell (RBC) phosphate release was linear for more than 1 h and dependent on the intracellular hydrolysis of organic phosphate esters. In uremics on chronic hemodialysis total phosphate release was significantly increased suggesting an elevated RBC energy metabolism. Ouabain-sensitive phosphate release, however, was decreased. For RBCs of controls and uremic subjects approximately 80% of inorganic phosphate liberated within the cell was recycled. Thus, RBC phosphate release represents 20% of intracellular phosphate ester metabolism. In uremia active electrolyte transport was diminished, suggesting an impaired Na-K-ATPase activity. It resulted in an increased RBC sodium and a decreased potassium concentration. The positive correlation between ouabain-sensitive rate constant for sodium efflux and ouabain-sensitive RBC phosphate release indicates that ouabain inhibition of phosphate elimination might be related to Na-K-ATPase. In RBCs of uremic subjects almost 4% of the increased energy metabolism was needed for active electrolyte transport mechanisms, in control RBCs 12% was required.
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