首页   按分类浏览 期刊浏览 卷期浏览 Synthesis and Biological Action of a New Cyclic AMP Analogue
Synthesis and Biological Action of a New Cyclic AMP Analogue

 

作者: Toshiaki Fujihashi,   Takahiro Ogata,   Tetsuo Ohkuma,   Tohru Endo,   Akira Kaji,  

 

期刊: Nucleosides and Nucleotides  （Taylor Available online 1992）
卷期: Volume 11, issue 2-4  

页码: 295-310

 

ISSN:0732-8311

 

年代: 1992

 

DOI:10.1080/07328319208021704

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

A new cyclic AMP analogue, adenosine- 3′, 5′-cyclic methyl phosphonate (cAMP-Me) was chemically synthesized. This compound was not a substrate for phosphodiesterase, and it did not activate cAMP-dependent protein kinases (type I or type II). However, it inhibited cAMP phosphodiesterase and protein kinase at milimolar concentration levels. It also inhibited malignant cell proliferation in vitro.

 

点击下载:  PDF (659KB)



返 回