Synthesis of sialyl-Lewis x (15) and sialyl-Lewis a (17) epitope analogs containing the 2-acetamido derivative ofN-methyl-1-deoxynojirimycin has been achieved. A suitably protected 2-acetamido- 1-deoxynojirimycin derivative5, prepared from 1-deoxynojirimycinviathe epoxide intermediate3, was successively coupled with methyl- 1-thioglycosides of L-fucose (6) and β-sialyl-(2→3)-D-galactose (9). The resulting tetrasaccharides (10and13) were each converted, by reductiveN-methylation and deprotection, into the desired epitope analogs.