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Analysis, design and modification of loop regions in proteins

 

作者: J. M. Thornton,   B. L. Sibanda,   M. S. Edwards,   D. J. Barlow,  

 

期刊: BioEssays  （WILEY Available online 1988）
卷期: Volume 8, issue 2‐3  

页码: 63-69

 

ISSN:0265-9247

 

年代: 1988

 

DOI:10.1002/bies.950080205

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

数据来源: WILEY

 

摘要:

AbstractLoop regions in proteins have traditionally been described as ‘random coil’, although they are known to adopt well‐defined conformations in most globular proteins. In this contribution we summarize the results of detailed analysis of the structures and sequences of these loop regions in proteins of known three‐dimensional structure. We also describe how these results can be used as an aid to protein design, modification and mo

 

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