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Synthesis and Preliminary Evaluation of 2-Chloroethylnitrosourea Derivatives of Sucrose

 

作者: Tetsuo Suami,   Tsuguhiro Kato,   Kazuaki Kanai,   Shuichi Ohki,   Hideyo Yamashita,  

 

期刊: Journal of Carbohydrate Chemistry  （Taylor Available online 1984）
卷期: Volume 3, issue 3  

页码: 417-427

 

ISSN:0732-8303

 

年代: 1984

 

DOI:10.1080/07328308408057906

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

2-Chloroethylnitrosourea derivatives of sucrose have been synthesized as potential antineoplastic agents. Two compounds: 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxysucrose and 6′-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6′-deoxysucrose exhibited significant antitumor activity against experimental leukemia L1210 in mice. Their chemical decomposition rates (T0.5) have been determined.

 

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